The Southwest African bioregion, located in the Afrotropical realm, runs the length of Namibia’s Atlantic Coast through the southern half of Angola. It is an extremely arid region consisting of sandy coastal deserts, steppe, and dry savanna woodlands with four ecoregions altogether totaling approximately 27 million hectares of land area.

The Greater Karoo & Kalahari bioregion, located in the Afrotropical realm, encompasses the large expanse of dry savannas and woodlands between the Highveld in South Africa and the coastal deserts of Namibia. It contains four ecoregions totaling approximately 121 million hectares of land area.

The Southeast African bioregion, located in the Afrotropical realm, is centered around the inland Highveld, a plateau formed by the Great Escarpment ridge in South Africa dominated by mountain grasslands, which transition to subtropical grasslands in the east and mid-altitude bushlands in the north. It contains five ecoregions.

The South African Cape bioregion is the only Mediterranean bioregion in the Afrotropical realm. It is confined to the small southern coastline of the continent and incorporates the succulent Karoo ecoregion, which is tightly interlinked with the dominant shrublands. It contains five ecoregions.

The Tristan Volcanic Islands bioregion, located on the western edge of the Afrotropical realm, is a remote group of small islands in the far south of the Atlantic Ocean. The islands contain predominantly temperate grasslands with one single ecoregion but it has numerous endemic plant species including the tree fern.

The West African Coastal Forests & Savanna bioregion, located in the Equatorial Afrotropics, consists of tropical coastal forests and mangroves as well as Guinean mountain forests and forest-savanna. With seven ecoregions it has a land area more than 113 million hectares, not including mangroves or adjacent marine areas.

The Gulf of Guinea Coastal Forests & Mangroves Bioregion, located in the Equatorial Afrotropics subrealm, consists of lush tropical forests and mangroves lining the coastline of Gabon, Equatorial Guinea, Cameroon, and Nigeria, and includes Bioko, São Tomé, Príncipe, and Annobón islands. It contains eight ecoregions.

North Congolian Forest-Savannas bioregion, located in the Equatorial Afrotropics, includes the Cameroon Highlands to the west and extends above the Congolian lowland forests to the Sudd in the east. It contains two ecoregions totaling approximately 74.5 million hectares.

The North Congolian Lowland bioregion, located in the Equatorial Afrotropics, includes the densely forested lowland areas above the Congo River, bounded to the east by the Albertine Rift. It is divided into western and eastern halves and is made up of two major ecoregions totaling 95 million hectares.

The Central Congolian bioregion, located in the Equatorial Afrotropics, is in the Cuvette Centrale region of the Congo Basin, south of the Congo River. It consists of dense wet forests and swamps, storing enormous amounts of carbon and harboring diverse wildlife, including lowland gorillas and the endemic peafowl. It is made up of three ecoregions totaling nearly 64 million hectares.

The South Congolian bioregion, located in the Equatorial Afrotropics, covers the area between the northern coast of Angola and mountains in the east of DRC, running along the Albertine Rift. It consists of tropical forest-savannas and woodlands running below the Equatorial forest zone with two ecoregions and adjacent marine areas.

The Victoria Basin bioregion, located in the Equatorial Afrotropics, is centered on Lake Victoria at the border between Kenya, Tanzania, and Uganda, and the surrounding forest-savanna. It contains three ecoregions.

The St. Helena & Ascension bioregion, located in the Sub-Equatorial Afrotropics, comprises a grouping of small volcanic islands in the middle of the Atlantic Ocean more than 800 nautical miles from the Gulf of Guinea. With two ecoregions it has a land area of approximately 22,000 hectares.

The Greater African bioregion is the largest in the Afrotropical realm, covering the entire width of the continent from the drylands and grasslands of southern Africa north to the beginning of the Equatorial forest zone, extending to the southern shore of Lake Victoria. The bioregion contains 20 distinct ecoregions.

The Mascarene bioregion, located in the Afrotropical realm, is an archipelago of islands in the Indian Ocean just east of Madagascar, which includes Mauritius, Réunion, and Rodrigues, plus a variety of reefs, atolls, and small islands. The bioregion is dominated by one ecoregion which include a diverse range of rainforests, cloud forests, swamp forest, and lowland dry forests.

The Amsterdam-Saint Paul bioregion, located in the far south of the Indian Ocean, is at the furthest edge of the Afroptropical realm, at the transition between the Indomalayan and Antarctic realms. Its two islands are dominated by temperate grasslands with one single ecoregion and adjacent marine areas.

The East African Coastal bioregion, located in the Afrotropical realm, extends in a narrow band nearly the entire length of Africa’s eastern coast. It consists of tropical and subtropical moist forests including seven ecoregions.

The Madagascar bioregion, located in the Afrotropical realm, is separated from the African continent by the Mozambique Channel dominated by humid tropical forests in the east, drylands in the south, and dry forests in the north. It contains seven terrestrial ecoregions as well as the Madagascar Mangroves with a total land area of more than 59 million hectares, making it the fourth largest island in the world.

The Seychelles & Comoros bioregion, located in the Afrotropics realm, consists of two archipelagos of islands in the Indian Ocean north of Madagascar and contains three ecoregions covering an area of approximately 250,000 hectares, not including reefs and adjacent marine areas.

The Sahel Acacia Savannas bioregion, located in the Sub-Saharan Afrotropics, consists almost entirely of one ecoregion that spans across the width of the continent from northern Senegal and Mauritania on the Atlantic coast to Sudan and Eritrea on the Red Sea. It also includes two very unique flooded savanna ecoregions, and altogether the bioregion has a land area of nearly 377 million hectares.

The South Red Sea & Gulf of Aden Coastal Drylands bioregion, located in the Sub-Saharan Afrotropics, consists of 12 ecoregions encompassing the Horn of Africa, the southern Red Sea and Aden Sea, and the southernmost tip of the Arabian Peninsula. The bioregion is mostly desert with some drylands and scrublands and covers an area of approximately 78 million hectares, not including mangroves and adjacent marine areas in the Red Sea.

The Lake Turkana-Sudd Grasslands, Bushlands & Forests bioregion is located in the Sub-Saharan Afrotropics. It is a very complex assemblage of 11 ecoregions stretching from northern Cameroon to Ethiopia.

The West Sudanian Savanna bioregion, located in the Sub-Saharan Afrotropics, is made up of one large ecoregion stretching from the coast of Senegal to the eastern border of Nigeria.

The Cape Verde Islands bioregion, located in the Afrotropical realm, contains the group of ten volcanic islands off the coast of Senegal, is defined by one dry forest ecoregion with a total land area of approximately 450,000 hectares. Cape Verde's isolation has resulted in the islands having a number of endemic species, particularly birds and reptiles, many of which are endangered..